Whole genome and whole exome sequencing are incredible. They’re also… a lot. As in thousands to millions of variants staring back at you, asking for classification, a lot. And while comprehensive data is powerful, most clinical questions don’t require analyzing everything, everywhere, all at once. That’s where Virtual Gene Panels in VarSeq come in.
Instead of re-running assays or maintaining dozens of physical panels, Virtual Gene Panels let you start big, at the WGS long-read sequencing level, and then laser-focus your analysis down to the genes that actually matter for the case at hand. Think of it as genomic zoom: same data, sharper picture.
Need a clinically curated panel? VarSeq can pull from trusted sources like the UK Biobank, whose rigorously developed gene panels reflect some of the most robust population-scale research available today. You can even pick the ‘level’ of genes you want to include in that panel, from the clinically validated gene list, or a broader, more research-based list.
Prefer something even more tailored? Build custom panels using HPO or MONDO disorder terms, or create one entirely from scratch for your lab’s specific needs. Flexible, reproducible, and fully under your control.
And because surprises happen (genomically speaking), Virtual Gene Panels also make it easy to run a parallel panel for ACMG Secondary Findings. Primary indication up front, secondary findings quietly monitored in the background, so if something important “pops up,” it doesn’t slip through the cracks.
Better yet, VarSeq can automate all of this. With the Match Panels per Sample algorithm, the right virtual gene panel is applied automatically on a per-patient basis. No manual juggling. No second-guessing. Just fast, consistent, scalable analysis—especially critical when working with large datasets and long-read technologies.
Big data doesn’t have to mean big headaches. With Virtual Gene Panels in VarSeq, you get the best of both worlds: comprehensive sequencing paired with focused, automated interpretation. All signal, no noise. If you would like to know more about how Virtual Gene Panels can be used in your workflow, please reach out to [email protected]!
