PBAT Bibliography and Citations

Published articles and papers related to the FBAT/PBAT methods, part of the HelixTree suite of genetics analysis tools:

2008

  • I. Ionita-Laza, C. Lange, et. al. (2008) On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. Genetic Epidemiology. 32(3): 273 - 284.

2004

  • Christoph Lange, Dawn DeMeo, Edwin K. Silverman, Scott T. Weiss and Nan M. Laird. (2004) PBAT: Tools for Family-Based Association Studies. American Journal of Human Genetics, Letter to the Editor 74:367-369.
  • Lange C, Blacker D, Laird N M. (2004) Family-based association tests for survival and times-to-onset analysis. Statistics in Medicine.
  • Lyon H, Lange C, Lake S L, Silverman E K, Randolph A G, Kwiatkowski D J, Raby B, Lazarus R, Weiland K M, Laird N M, Weiss S T. (2004) IL10 gene polymorphisms are associated with asthma phenotypes in children. Genetic Epidemiology 26:155-165.

2003

  • Lange C, DeMeo D L, Silverman E K, Weiss S T, Laird N M. (2003) Using the noninformative families in family-based association tests: a powerful new testing strategy. American Journal of Human Genetics 79:801-811.
  • Lange C, Lyon H, DeMeo D L, Raby B, Silverman E K, Weiss S T. (2003) A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Human Heredity 56:1017.

2002

  • DeMeo D L, Lange C, Silverman E K, Senter J M, Drazen J M, Barth M J, Laird N M, Weiss S T. (2002) Univariate and multivariate family based analysis of the arg130gln polymorphism of the IL13 gene in the childhood asthma management program. Genetic Epidemiology 23:335-349.
  • Lange C, DeMeo D L, Laird N M. (2002) Power and design considerations for a general class of family-based association tests: quantitative traits. American Journal of Human Genetics 71:1330-1341.
  • Lange C, Laird N M.(2002) Analytical sample size and power calculations for a general class of family-based association tests: dichotomous traits. American Journal of Human Genetics 71:575-584.
  • Lange C, Laird N M. (2002) On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power and optimality considerations. Genetic Epidemiology 23:165-180.
  • Lange C, Silverman E K, Xu X, Weiss S T, Laird N M. (2002) A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics 4:195-206.
  • Lange C, Whittaker J C, Macgregor A J. (2002) Generalized estimating equations: a hybrid approach for mean parameters in multivariate regression models. Statistical Modeling 2:163-181.

2001 & Older

  • Horvath S, Xu X, Laird N M. (2001) The family based association test method: strategies for studying general genotype-phenotype associations. European Journal of Human Genetics 9:301 306.
  • Laird N M, Horvath S, Xu X. (2000) Implementing a unified approach to family based tests of association. Genetic Epidemiology Supplement 19:36-42.
  • Lake S L, Blacker D, Laird N M. (2000) Family-based tests of association in the presence of linkage. American Journal of Human Genetics 67:1515-1525.
  • Monks S A, Kaplan N L. (2000) Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus. American Journal of Human Genetics 66:576-592.
  • Rabinowitz D, Laird N M. (2000) A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Human Heredity 50:211-223.
  • Abecasis G R, Cardon L R, Cookson W O C. (1999) A general test of association for quantitative traits in nuclear families. American Journal of Human Genetics 66: 279-292.
  • Horvath S, Laird N M. (1998) A discordant-sibship test for disequilibrium and linkage: no need for parental data. American Journal of Human Genetics 63:1886-1897.
  • Liang K-Y, Zeger S L. (1986) Longitudinal data analysis using generalized linear models. Biometrika 73:13-22.


Published papers and articles about studies in which the PBAT software is cited (sorted by date):


  • Lasky-Su J, et al. (2008) On the Replication of Genetic Associations: Timing Can Be Everything! The American Journal of Human Genetics, 82(4): 849-858, doi:10.1016/j.ajhg.2008.01.018.
  • Hunninghake GM et al. (2008) Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations. Journal of Allergy and Clinical Immunology, doi:10.1016/j.jaci.2008.03.015.
  • Alan Herbert, et al. (2006) A Common Genetic Variant Is Associated with Adult and Childhood Obesity. Science 312: 279-283.
    •