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" 'Where is the missing heritability?' is a question asked frequently in genetic research. The difficulty seems to come down to the common disease/common variant hypothesis not holding up." » Read more
TABLE OF CONTENTS
Tutorial: Family-Based Analysis
Created: November 2009
Level: Intermediate
Modules: HelixTree, PBAT
This tutorial leads you through family-based association analysis using the PBAT statistical package incorporated into SNP & Variation Suite 7. Covered workflows include data preparation, quality assurance testing, association analysis, and basic visualization of results.
Golden Helix PBAT is developed in collaboration with Dr. Christoph Lange of Harvard University's School of Public Health.
NOTE: The data used in this tutorial is for demonstration purposes only as it consists of simulated phenotypic information for the CEU HapMap samples.
Requirements
To complete this tutorial you will need to download and unzip the following file, which includes several datasets.
| Download | Files | Size |
 |
PBAT-Tutorial.zip | 660KB |
Files included in the above ZIP file:
- CEU - PED.csv - Actual pedigree information for the CEU HapMap samples (Phase III).
- CEU - SIM - PHENO.csv - Simulated phenotype and clinical data.
- CEU - GENO - Chr22.dsf - Actual chromosome 22 genotypes for the CEU HapMap samples (Phase III) generated from a combination of Affymetrix and Illumina arrays.
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