Long Read Part 3: Repeat Expansions

May 19, 2026

Short tandem repeats (STRs) are among the most challenging variants to characterize with traditional sequencing technologies. Many clinically significant STR expansions span hundreds or thousands of base pairs, far exceeding the read lengths of short-read platforms. As a result, countless disease-causing repeat expansions have historically gone undetected in genomic workflows,…

Read more →

April 2026 Customer Publications

Apr 30, 2026

April’s customer publications with clinical genomic insights across healthy aging genes in Super Seniors, chronic kidney disease, and breast cancer risk stratification. Each month, we highlight new research from the scientific community that advances our understanding of complex genetic diseases and showcases the tools researchers rely on for precise variant…

Read more →

Long-Read Part 1: Structural Variant Analysis

Apr 28, 2026

End-to-End Structural Variant Analysis for Long-Read Data with VarSeq and VSWarehouse Long-Read Data Long-read sequencing technologies like PacBio HiFi have transformed our ability to detect structural variants (SVs) with greater accuracy and resolution than ever before. Unlike short-read sequencing, which often struggles to span the repetitive or complex genomic regions…

Read more →

Warehouse Workflow Spotlight: Part 3

Apr 14, 2026

Many labs already use DRAGEN upstream, but want more control over what happens after variant calling is complete. VSWarehouse 3 connects those outputs to downstream tertiary workflows that labs can automate, configure, and adapt to their own interpretation and reporting process. Using DRAGEN with VSWarehouse 3: A Better Path to…

Read more →

Your Variant Knowledge Base

Apr 9, 2026

Getting the Most from Assessment Catalogs in VSWarehouse One of the most frequent questions from our customers is some version of: “How do we keep our team from re-evaluating the same variant every time it shows up in a new sample?” The answer, in nearly every case, is assessment catalogs and more…

Read more →

VSWarehouse for Genome Centers: Scalable, Secure Whole-Genome Infrastructure for Modern Sequencing Programs 

Dec 12, 2025

Thank you to everyone who joined our recent webcast, “VSWarehouse for Genome Centers: Scalable, Secure Whole-Genome Infrastructure for Modern Sequencing Programs,” presented by Gabe Rudy on December 10, 2025. We appreciate the strong attendance and the excellent questions regarding the operational and security needs of modern genome centers.  For those…

Read more →

Challenging Genomic Regions: Paraphase Integration in VSWarehouse 3

Dec 9, 2025

Short-read sequencing often fails to capture clinically actionable information from challenging genomic regions. While long-read sequencing now enables accurate and comprehensive detection of complex variants, there are still regions of the genome that remain notoriously difficult to analyze. Unfortunately, many of these regions contain genes that are highly relevant to…

Read more →

Integrating PacBio Somatic Workflows into VSWarehouse 3.0

Nov 21, 2025

As long-read sequencing solidifies its role in clinical and translational research, labs are increasingly seeking streamlined methods to transition from raw data to actionable results. With the release of VSWarehouse 3.0, Golden Helix now supports a fully integrated implementation of PacBio’s somatic workflow, providing users with a powerful, centralized environment…

Read more →

Introducing VarSeq 3.0.0: Faster, Smarter, Fully Integrated with VSWarehouse 3

Nov 7, 2025

VarSeq 3.0.0 is officially here, and it’s one of our most significant releases yet! The headline feature of this update is full integration with VSWarehouse 3, including a new login system that supports both single-user mode and server-managed authentication. Users can now choose to work locally or seamlessly store projects…

Read more →

Clinical Variant Interpretation at Scale: Reflections from ASHG 2025

Oct 27, 2025

Recently, Golden Helix attended the ASHG 2025 conference, where we had the opportunity to showcase our partnership with Genomenon. This collaboration took center stage at both our booth and Genomenon’s CoLab session, Automating Genomic Workflows: Cutting Interpretation Time, Accelerating Turnaround, and Increasing Diagnostic Yield. Our discussions centered on a problem…

Read more →

Introducing VSWarehouse 3 Installation Cloud Servers

Sep 15, 2025

As precision medicine advances, clinicians and diagnostic labs face an ever-increasing volume of genetic data and analytical complexity. Meeting this demand requires tools that streamline data management and automate bioinformatic workflows to deliver timely, accurate diagnoses. By bringing data management, diagnostic workflow automation, and reporting into a single platform, VSWarehouse…

Read more →

Webcast Recap: Secondary NGS Workflow Automation in VSWarehouse

Sep 5, 2025

Recently, Golden Helix Field Application Scientists Rana Smalling and Andrew Legan led a webcast on Secondary NGS Workflow Automation in VSWarehouse. The presentation walked through the process of turning FASTQ data into completed VarSeq projects and clinical reports with just a click of a button. During the Q&A, a few…

Read more →

Take Control Over Your Variant Assessment Catalogs

Aug 5, 2025

Over the past several months, we’ve highlighted the powerful new capabilities introduced with VarSeq Warehouse 3.0. Today, I’d like to focus on a familiar feature that’s been thoughtfully enhanced, assessment catalog record management. This update significantly improves data quality, role-based collaboration, and regulatory compliance. Variant assessment catalogs have always been…

Read more →

Automating Pharmacogenomics Workflows with VSWarehouse 3: From Variants to Clinical Reports

Jul 24, 2025

In our recent webcast, we explored how VSWarehouse 3 streamlines and automates pharmacogenomics workflows, transforming raw NGS data into actionable clinical reports. This blog post recaps the webcast, breaking down each component of the standard pharmacogenomics workflows to demonstrate how laboratories can achieve end-to-end automation in pharmacogenomic (PGx) testing. Golden…

Read more →

Deploying VSWarehouse 3 With Ease

Jun 26, 2025

Managing genomic workflows at scale has always required a bit of IT expertise. The reality is, Next Generation Sequencing data is quite large and requires substantial compute resources to process. Clinical labs must carefully plan how to scale their IT resources to match their genomic testing workloads. Some labs prefer…

Read more →