Next-generation sequencing (NGS) data analysis often involves multiple steps from variant annotation, filtering, interpretation, visualization, and report generation. Repeating these steps manually for each new project can be error-prone and inefficient. In clinical and regulated environments, we recognize that consistency is critical. That’s why VarSeq offers robust support for workflow templates, enabling users to save, share, and reuse entire analysis pipelines with just a few clicks.

Project Templates in VarSeq

Once you’ve created a workflow that fits your lab’s specifications in VarSeq, whether a somatic gene panel, a tumor/normal analysis, a WGS singleton, or a Trio, you can save it as a project template. These templates retain every setting from your analysis pipeline:

• Variant filters
• Annotation sources
• Applicable evaluation scripts (see more in our recent webcast!)
• External data inputs (like PGx diplotypes, CNVs from a manifest, or other patient demographics)
• Visualization views in GenomeBrowse

This means every future project using that template starts from a fully configured baseline, dramatically reducing setup time and eliminating variability between runs.

Template versioning is key for labs undergoing validation or maintaining CLIA/CAP-compliant processes. VarSeq allows you to version your templates so you can track changes, compare updates, and maintain full transparency over time. This ensures that updates to workflows, such as integrating a new filter or annotation source, are controlled and documented.

Annotating for Consistency

Speaking of annotations: VarSeq gives you the option to lock annotation sources to specific versions, ensuring that your analysis remains consistent even as public databases evolve. Whether you’re pulling from ClinVar, gnomAD, or your internal curation database, you can trust that your pipeline produces the same results today as it did during validation.

Template Sharing

Templates are also easily shared across teams or sites, making them a valuable tool for standardizing workflows in multi-user environments. If you’re onboarding new analysts or collaborating across institutions, sharing a validated template ensures that everyone is analyzing data the same way with no room for interpretation drift.

Overall, VarSeq’s workflow templates help you do more than just automate analysis. They help you enforce reproducibility, support regulatory validation, and scale your lab’s capabilities with confidence. From external manifests to GenomeBrowse views, every setting is preserved so you can focus on results, not reconfiguration.

Do you have questions about VarSeq? Email [email protected], and one of our team members will be happy to assist you!