The VSPGx module supports laboratory-developed PGx tests with star allele calling, metabolizer phenotyping, and CPIC/FDA guideline matching, packaged into customizable report templates.
Amitriptyline: Avoid use due to risk of sub-therapeutic response or toxicity. Consider alternative medication.
VSPGx is part of VarSeq Suite, licensed for Research Use Only. Intended for laboratory-developed test (LDT) development, method validation, and internal research workflows. Customers are responsible for clinical validation and regulatory compliance of any test built using VSPGx. Regulatory details.
VSPGx automates the translation of genotypes into star allele nomenclature and CPIC metabolizer phenotypes, providing labs with a reproducible pathway from raw data to PGx reports.
Automate the mapping of SNVs, indels, and structural variants to standardized star allele nomenclature. Support for complex genes like CYP2D6, including copy number events.
Native integration with CPIC and FDA guidelines. Automatically map diplotypes to phenotypes and surface evidence-based prescribing recommendations.
Generate laboratory-branded PGx reports surfacing current medications, gene-drug interactions, and CPIC dosing guidance for review by qualified laboratory personnel.
Our structured algorithm ensures reproducible results across any genomic dataset, from targeted panels to whole genomes.
Identify variants at CPIC-specified positions and map them to standardized star allele nomenclature (e.g., CYP2C19 *2, *17).
Pair identified alleles per gene to assign diplotypes. Calculate activity scores and map to metabolizer phenotypes (e.g., Poor, Normal, Ultra-Rapid).
Match phenotypes to published CPIC and FDA guidance. Filter results by current medications to surface relevant recommendations for review.
VSPGx is designed for assay flexibility, supporting any data source that provides genotype calls. No specialized PGx-only sequencing is required.
Process VCF inputs from targeted gene panels, clinical exomes, and whole genomes, as well as microarray-derived genotypes.
Incorporate copy-number events (e.g., CYP2D6 *1xN duplications or *5 deletions) directly into phenotype determination.
Scale your PGx operations with VSPipeline and VSWarehouse integration, enabling end-to-end automated pipelines from raw data to report.
CYP2D6 metabolizes many opioids, antidepressants, and antiemetics. CPIC publishes Level A guidance for codeine, tramadol, ondansetron, and several SSRIs based on metabolizer phenotype.
CYP2C19 drives clopidogrel activation. CPIC publishes Level A guidance linking diplotype to therapeutic response in cardiovascular care.
SLCO1B1 variants affect statin transport. CPIC publishes Level A guidance for statin dosing and selection based on transporter function.
Request a personalized evaluation with your own pharmacogenomics data.
Deep dives into CPIC implementation, star allele calling, and PGx reporting workflows.
VSPGx is part of VarSeq Suite, licensed for Research Use Only. Not available as an in vitro diagnostic medical device. Intended for LDT development, method validation, and internal research workflows.
Join laboratories worldwide using VSPGx for CPIC-aligned PGx pipelines and customizable report templates.