VSClinical automates evidence assembly and applies ACMG/AMP guidelines to classify germline and somatic variants with consistency. Move from filtered candidates to defensible clinical decisions.
VSClinical implements all 28 ACMG criteria for germline classification and AMP tier evidence levels for somatic interpretation, reducing subjectivity and accelerating clinical decisions.
Automatically evaluates each variant against all applicable ACMG criteria with scored recommendations and supporting evidence. The auto-classifier surfaces pathogenic variants and quickly identifies benign calls to accelerate throughput.
Aggregates population frequencies from gnomAD, ClinVar submissions at the codon level, functional predictions from SIFT and PolyPhen2, conservation scores, and mutational hotspot analysis into a single structured view.
Facts and evidence statements collected during classification flow directly into customizable Word-based report templates. Generate DOCX or PDF reports with sign-off workflows for clinical delivery.
VSClinical's guided workflow walks clinicians through evidence evaluation for each variant, documenting every decision for a defensible audit trail.
Automatically check gnomAD and 1000 Genomes frequencies by sub-population. Variants exceeding benign allele frequency thresholds (BA1, BS1) are flagged immediately, clearing the majority of candidates without manual review.
The auto-classifier evaluates each variant against all 28 ACMG criteria — scoring pathogenic (PVS1 through PP5) and benign (BA1 through BP7) evidence with supporting data displayed for every recommendation.
Review ClinVar submissions, mutational hotspot neighbors, functional predictions, conservation scores, and literature citations. Accept, reject, or upgrade/downgrade individual criteria with documented rationale.
The scoring engine applies ACMG combining rules to assign Pathogenic, Likely Pathogenic, VUS, Likely Benign, or Benign classification. Real-time probability updates reflect each scored criterion.
Evidence statements collected during classification auto-populate customizable clinical report templates. Finalize and render to DOCX or PDF with integrated sign-off workflow.
VSClinical provides distinct guided workflows for germline (ACMG) and somatic (AMP) variant classification, covering the full spectrum of clinical genomic testing in one platform.
Every classification decision is stored in your lab's variant knowledgebase. When the same variant appears in a future sample, prior assessments and evidence are surfaced automatically, reducing rework as your lab scales.
All 16 pathogenic and 12 benign criteria evaluated automatically with supporting evidence for each recommendation.
Somatic variants classified into Tiers I–IV based on Level A–D therapeutic, diagnostic, and prognostic evidence from Golden Helix CancerKB, CIViC, and DrugBank.
Classify copy number variants using ACMG/ClinGen CNV guidelines and gene fusions using AMP somatic workflows — all within the same interface.
For somatic cases, search NCI-funded trials by biomarker, tumor type, geographic location, and recruitment status directly from the classification workflow.
Request a personalized evaluation with your own variant data.
ACMG-guided classification is the standard for rare Mendelian disease testing. VSClinical's auto-classifier and trio analysis support help labs shorten diagnostic odysseys and deliver defensible findings.
AMP-guided somatic classification connects tumor variants to FDA-approved therapies and clinical trials. CancerKB provides report-ready interpretations for oncologist-ready reports.
Classify germline pathogenic variants in BRCA1/2, Lynch syndrome genes, and other hereditary cancer panels. ClinVar integration surfaces prior classifications at the amino acid level for consistent assessment.
Deep dives into ACMG/AMP classification workflows, evidence assembly strategies, and clinical reporting best practices.
Join clinical laboratories worldwide using VSClinical for ACMG/AMP-guided variant classification and reporting.