CADD Scores: Rank and Filter in Harmony!
![VSClinical algorithm](https://www.goldenhelix.com/blog/wp-content/uploads/2016/05/varseq_symbol-176x176.png)
There used to be much energy expended at conferences, bioinformatics forums and even publications about what was the better strategy for interpreting variants of clinical significance: Rule-based filtering and classification mechanisms or rank-based prioritization through all-encompassing “pathogenicity” scores. Both have shown to be effective. Rule-based systems, as exemplified in this filtering diagram in Baylor’s ground-breaking paper on clinical whole-exome sequencing… Read more »