Address the unique challenges of whole genome sequencing (WGS) analysis. From petabyte-scale data management to clinical structural variant detection and non-coding region interpretation, VarSeq provides the end-to-end genomic analysis software solution.
WGS interpretation software must handle more than just variant calling. Our unified platform integrates high-performance secondary analysis with clinical-grade tertiary analysis, delivering a seamless transition from raw data to actionable insights.
Powered by Sentieon's optimized implementation of GATK models, achieve mathematically equivalent results with massive throughput gains. Sentieon DNAscope provides improved accuracy through enhanced active region detection, powerful local assembly, and pre-trained machine learning models for both short-read and long-read sequencers.
Sentieon DetailsImport and process genome-scale VCFs with multi-threaded performance. VarSeq handles the unique data scale of WGS without the performance bottlenecks found in legacy tools.
Analysis WorkflowOne-click generation of customizable clinical reports. Standardize your results with ACMG/AMP scoring, literature links, and lab-specific branding.
Reporting DetailsWGS analysis requires more than just SNV calling. VarSeq provides a unified environment for detecting and interpreting the full range of variation at genome scale.
Automate the interpretation of complex structural variants and copy number changes. Apply ACMG/ClinGen guidelines to ensure consistent classification across whole genome datasets.
CNV InterpretationAutomate star-allele calling and drug-gene interpretation. Leverage CPIC guidelines to deliver actionable pharmacogenomic insights directly from WGS data.
PGx CapabilitiesAnalyze data from any sequencing technology. VarSeq provides a unified platform for both short-read and long-read WGS, resolving complex regions with ease.
Long-Read SolutionsManaging genome-scale data requires an enterprise-grade infrastructure. VSWarehouse centralizes your variant assessments, clinical reports, and longitudinal data into a secure, searchable repository — whether deploying on-premise, in a private cloud (BYOC), or air-gapped environment.
Generate cohort-level allele frequencies from thousands of genomes to inform clinical classification.
Full automation from FASTQ to report, including CNV computation and cohort management.
Deploy anywhere to meet compliance requirements: cloud, on-prem, or hybrid.
Supported by Golden Helix Enterprise Solutions
WGS captures the full spectrum of variation — coding, non-coding, and structural — to diagnose cases that remain unresolved after exome or panel testing.
Whole genome sequencing reveals the complete landscape of somatic variation including structural rearrangements, gene fusions, and non-coding driver mutations.
Enterprise-scale WGS programs require automated pipelines, population-level cohort management, and robust infrastructure for high-throughput genome interpretation.
VarSeq provides a comprehensive ecosystem for whole genome sequencing in clinical and research laboratories.
Integrated clinical-grade CNV calling from genome read depths. Resolve large-scale structural events.
Resolve complex SVs and tricky genes with PacBio HiFi and Oxford Nanopore long-read sequencing.
High-performance visualization of genome-scale BAM and VCF files with interactive annotation overlays.
VSPipeline automation from FASTQ to clinical report for hands-off high-throughput WGS processing.
Bioinformatics experts demonstrate advanced genome analysis and population scale interpretation.
Unlock the potential of whole genome sequencing for your laboratory with VarSeq's enterprise-scale genomic analysis software.