In 1914, the German cytologist Theodor Boveri coined the phrase “Cancer is a disease of the genome”. At this time, his ideas were as equally revolutionary as they were highly contested. Fast forward. More than a hundred years later, Next-Generation Sequencing effectively permits a highly sensitive analysis of cancer cells. It can help us to understand mutations associated with cancer development and progression. It also reveals other genomic rearrangements previously unknown to occur in the cancer genome. Translation of these findings for clinical purposes is an increasing part of standard care today.

I fully believe that next-generation sequencing will rapidly become a powerful tool for the personalized diagnosis and management of cancer. This eBook focuses on the parts of this process that are best understood: Cancer Gene Panels. This second edition will also show how a Tumor/Normal analysis can be conducted. This is typically more useful leveraging whole exome/genome data. We also added a case study to show how VarSeq is deployed in leading institutions such as the University of Iowa.

Please feel free to download your free copy here.