Genetic Testing for Cancer

In 1914 the German cytologist Theodor Boveri coined the phrase "Cancer is a disease of the genome". At this time his ideas were equally revolutionary as they were highly contested. Fast forward. More than a hundred years later, Next-Generation Sequencing effectively permits a highly sensitive analysis of cancer cells. It can help us to understand mutations associated with cancer development and progression. It also reveals other genomic rearrangements previously unknown to occur in the cancer genome. Translation of these findings for clinical purposes is increasingly part of standard care today. I fully believe that next-generation sequencing will rapidly become a powerful tool for the personalized diagnosis and management of cancer.

This eBook will cover:

  • Lung cancer as an example for genomic testing
  • Conducting a gene panel base cancer diagnosis
  • How a Tumor/Normal analysis can be conducted
  • How Copy Number Variations (CNVs) can be used in the diagnostics process
  • A practical case-study of how VarSeq is deployed in leading institutions such as the University of Iowa


About the Author
About the Author

Dr. Andreas Scherer is CEO of Golden Helix. The company has been delivering industry leading bioinformatics solutions for the advancement of life science research and translational medicine for over a decade. Its innovative technologies and analytic services empower scientists and healthcare professionals at all levels to derive meaning from the rapidly increasing volumes of genomic data produced from microarrays and next-generation sequencing. With its solutions, hundreds of the world’s top pharmaceutical, biotech and academic research organizations are able to harness the full potential of genomics to identify the cause of disease, improve the efficacy and safety of drugs, develop genomic diagnostics and advance the quest for personalized medicine. Golden Helix products and services have been cited in over 1100 peer-reviewed publications.

He is also Managing Partner of Salto Partners, a management consulting firm headquartered in the DC metro area. He has extensive experience successfully managing growth as well as orchestrating complex turnaround situations. His company, Salto Partners, advises on business strategy, financing, sales and operations. Clients are operating in the high tech and life sciences space.

Dr. Scherer holds a PhD in computer science from the University of Hagen, Germany, and a Master of Computer Science from the University of Dortmund, Germany. He is author and co-author of over 20 international publications and has written books on project management, the Internet and artificial intelligence. His latest book, “Be Fast Or Be Gone”, is a prizewinner in the 2012 Eric Hoffer Book Awards competition, and has been named a finalist in the 2012 Next Generation Indie Book Awards!