The State of Variant Annotation: A Comparison of AnnoVar, snpEff and VEP
![](https://www.goldenhelix.com/blog/wp-content/uploads/2014/06/different-ways.jpg)
Up until a few weeks ago, I thought variant classification was basically a solved problem. I mean, how hard can it be? We look at variants all the time and say things like, “Well that one is probably not too detrimental since it’s a 3 base insertion, but this frameshift is worth looking into.” What we fail to recognize is… Read more »